S. George Djorgovski is a Professor of Astronomy and the founding Director of the Center for Data-Driven Discovery. He has worked in many areas of astronomy and cosmology, and has led several sky surveys, currently the Catalina Real-Time Transient Survey that explores transient and variable objects and phenomena in the universe. He is one of the founders of the Virtual Observatory framework, and of the emerging field of Astroinformatics. His scientific interests are centered on the questions of how is computing and information technology changing the ways we do science, scholarship, and education in the 21st century.